The hazardous air quality poses significant health risks, especially to sensitive groups such as children, the elderly, and individuals with pre-existing respiratory or cardiovascular conditions. PM2.5 particles in the smoke can penetrate deep into the lungs and bloodstream, potentially triggering asthma attacks, respiratory issues, and cardiovascular problems. Residents in areas with AQI levels above 150 are advised to limit outdoor activities. The highest risk areas include Niagara Falls, Fredonia, and parts of New York City, Long Island, and the lower Hudson Valley.